EFEKTIVITAS ANTIHIPERGLIKEMIK PADA KELINCI JANTAN DARI EKSTRA ETANOL BUNGA TELANG (Clitoria Ternatea)

riana Versita

Sari


Telang flower plant (Clitoria ternatea) is a leguminous plant belonging to the Fabaceae family, containing bioactive compounds that are useful for treatment. Its ability as a biologically active compound gives a great role to human interests. Phenolic compounds have a positive correlation with antioxidant activity, so that polyphenols are probably the compounds that have the most potential to contribute anti-radical activity in telang flower. Telang flower extract has many properties so it is used as a traditional medicine for several diseases. A number of studies have shown that flavonoids have antiviral, anti-allergic, antiplatelet, antidiabetic, diuretic, anti-inflammatory, antitumor, and antioxidant activities. The phytochemical content of telang flower which is efficacious as antidiabetic / antihyperglycemic is saponins and flavonoids. Based on this, a preliminary study was conducted to determine the effectiveness of ethanol extract of telang flower (Clitoria ternatea) against antihyperglycemic in male rabbits. This type of research is a laboratory experiment. Telang flower powder simplicia (Clitoria ternatea) was extracted using the maceration method. Telang flower (Clitoria ternatea) ethanol extract was made in 3 concentrations, namely 2%, 3% and 4%. Antohyperglycemic effectiveness test used 3 groups, namely negative control (without treatment), positive control (Glibenclamide), ethanol extract of telang flower (Clitoria ternatea) 2%, 3% and 4%, against 4 white rabbits weighing 3-3.5 kg and given sucrose, carried out until the 8th day. The data were statistically processed using One Way ANOVA (Analysis Of Variant). In conclusion, giving ethanol extract of telang flower (Clitoria ternatea) with concentrations of 2%, 3%, and 4% at 60 minutes gave an effective and significant reduction in blood glucose levels compared to negative control and positive control.


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Andriani, D dan Murtisiwi, L. 2018. Penetapan kadar fenolik total ekstrak etanol bunga telang ( Clitoria Ternatea ) dengan spektrofotometri UV Vis. Cendikia Journal of Pharmacy, 2 ( 1 ) : 32 – 38.

Barhe, T.A and Tchouya, G.R. 2014. Comparative study of the anti-oxidant activity of the total polypenol extracted from hibiscus sabdariffa L. Glicinemax L. Meer.. yellow tea and red wine through reaction with DPPH Free Radikal. Arabian Journal of chemistry

Budiasih, K. S., 2017. Kajian Potensi Farmakologis Bunga Telang ( Clitoria Ternatea ). Prosiding Seminar Nasional Kimia UNY : 201 – 206

Jin, T.Y., Saravanakumar, K., and Wang, M.H. 2018. In Vitro and in vivo antioxidant properties of water and methanol extracts of linden bee pollen. Biocatalysis and agricultural biotechnoly, 13 ( 186 – 189 ).

Kazuma K, Noda N, Suzuki M. 2013. Malonylated flavonol glycosides from the petals of Clitoria ternatea. Phytochemistry, 62 (2), 229- 237.

Kosai, P., kanjana sirisidthi, Kanita Jiraungkoorsul and Wanne Jirangkoorsul. 2015. Review on Ethnomedicinal uses of Memory Boosting Herb, butterfly pea, clitoria ternatea. Journal of natural remedies, 15 (2), 71-76.

Kusrini, E., Tristantini, D., & Izza, N. (2017). Uji Aktivitas Ekstrak Bunga Telang (Clitoria ternatea L.) Sebagai Agen Anti-Katarak. Jurnal Jamu Indonesia, 2(1), 30-36. https://doi.org/10.29244/jji.v2i1.28

Lai-Cheong, J.E., and McGrath, J. A. 2017. Structur and function of skin, hair and nails. Medicine ( United Kingdom ), 45 (6), 347-351.

Lan, Z., Liu, J., Chen, L., Fu, Q., Luo, J., Qu, R., Ma, S. 2012. Danggui- Shaoyao – san ameliorates cognition deficits and attenuates oxidative stres related neuronal apoptosis in d- galactose-induced senescent mice. Joural of Ethnopharmacology, 141 (1), 386-395.

Liochev, S.I. 2013. Reactive Oxigen Spesies and the free radical of theory of aging. Free radical biology and medicine.

Marpaung AM. 2012. Optimasi proses ekstraksi antosianin pada bunga telang ( Clitoria Ternatean L)

Marpaung, A. M. (2020). Tinjauan manfaat bunga telang (clitoria ternatea l.) bagi kesehatan manusia. Journal of Functional Food and Nutraceutical, 1(2), 63-85. https://doi.org/10.33555/jffn.v1i2.30

Montenegoro, L. 2014. Nanocarries for skin delivery of cosmetic antioxidants. Journal of Pharmacy & Pharmacognosy Research, 2 ( 4 ), 73 – 92.

Choiriyah, Nurul Azizah. 2020. Kandungan Antioksidan Pada Berbagai Bunga Edible Di Indonesia. Agrisantifika Jurnal Ilmu Pertanian Vol 4, No 2 (2020)

Ponnusamy, S., Gnanaraj,W.E., Antonisamy, J.M.,2014.Flavonoid profile of Clitoria ternatea Linn.Traditional Medicine Journal, 19(1),1.

Ratz- Lyk, A., Arct, J., and Poytkowska, K. 2012. Methods for evaluation of cosmetic antioxidant capacit. Skin research and Technology, 18 (4), 421-430.

Riskesdas. 2013. Riset Kesehatan Dasar. Jakarta Badan Penelitian dan pengembangan kesehatan kementrian kesehatan RI. Akses internet online. www.litbang.depkes.go.id/sites/download/rkd2013/Laporan_Riskesdas2013.PDF

Salsabil. Adil, Athifah. Vifta, Rissa. Lila. Yuswantina, Richa (2020) Penentuan Kadar Fenolik Total Dan Aktivitas Antidiabetes Ekstrak Tanaman Telang (Clitoria Ternatea L.) Secara In Vivo. S1 thesis, Universitas Ngudi Waluyo.

Sharmila, G., V.S. Nikitha, S. S. Ilaiyarasi, K. Dhivya, V. Rajasekar, N.Manoj Kumar, K. Muthukumaran and C. Muthukumaran. 2016. Ultrasound assisted extraction of total phenolics from Cassia auriculata leaves and evaluation of its antioxidant activities. Industrial Crops and Products,84: 13-21

Stevani, Hendra. 2016. Modul Farmakologi. Jakarta : Pusdik SDM kesehatan Indonesia.

Swami, V.R., Neethu Varghese dan Ancy Simon. 2011. An investigation on cytoxic and antioxidant properties of Clotoria ternatea L. International Journal of Drug Discovery, 3 ( 1 ), 74 – 77.




DOI: https://doi.org/10.52161/jiphar.v9i1.389

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