Potensi Nutraseutikal Berbasis Kelapa Dalam Pencegahan dan Penatalaksanaan Sindrom Metabolik
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Sindrom metabolik (MetS) merupakan kumpulan kelainan metabolik termasuk obesitas sentral, dislipidemia, hipertensi, dan resistensi insulin yang meningkatkan risiko penyakit kardiovaskular dan diabetes tipe 2. Nutraseutikal berbasis kelapa, terutama virgin coconut oil (VCO), coconut water, dan produk turunan lainnya, menunjukkan potensi melalui kandungan medium-chain fatty acids (MCFA) seperti asam laurat, polifenol, dan antioksidan. Tinjauan literatur ini menganalisis bukti dari studi in vitro, hewan, dan uji klinis acak (RCT) mengenai efek pencegahan dan penatalaksanaan MetS. Metode pencarian dilakukan pada database PubMed, Scopus, dan Google Scholar hingga Juni 2026 dengan kata kunci terkait. Hasil menunjukkan VCO secara signifikan menurunkan trigliserida (TG) dan meningkatkan HDL-C, serta memperbaiki parameter glikemik danstres oksidatif pada pasien MetS, meskipun efek pada LDL-C dan berat badan bervariasi. Mekanisme melibatkan metabolisme cepat MCFA, aktivitas anti-inflamasi, dan modulasi mikrobiota usus. Dari hasul kajian literatur yang dilakukan disimpulkan bahwa nutraseutikal kelapa berpotensi sebagai adjuvan terapi, tetapi diperlukan studi jangka panjang lebih besar.
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DOI: https://doi.org/10.52161/jiphar.v13i2.988
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